01184nas a2200181   4500000000100000008004100001260001200042653001800054100001500072700001300087700001000100245006700110856007100177300000900248490000700257520072400264022001400988       2020                            d  bMedknow10aOphthalmology1 aRathinam S1 aParikh J1 aRao N00aOcular erythema nodosum leprosum: An immunohistochemical study  uhttp://www.ijo.in/temp/IndianJOphthalmol6892028-5794891_160548.pdf  a20280 v683 aEpiscleritis, scleritis, and anterior uveitis are common clinical manifestations of ocular leprosy. Erythema nodosum leprosum (ENL) is an acute, exaggerated systemic immunological reaction that complicates the course of this chronic indolent disease. We present an ocular immunohistochemical study of severe form of ENL involving even the ciliary body and choroid resulting in the perforation of the globe on the initiation of anti leprosy therapy. We used CD-3, CD-68, S-100, and CD-20 for immunohistochemistry. It revealed plenty of CD-3-positive T-cells and CD-68-positive macrophages and a few S-100 and CD-20-positive cells. The inflammatory exudates stained positive for IgG and IgM. The diagnosis was ocular ENL.  a0301-4738