01050nas a2200193   4500000000100000008004100001260001200042100001100054700001100065700001100076700000900087700000900096700001000105700001200115700001100127245015700138520054700295022001400842       2020                            d  c04/20201 aWang H1 aWang C1 aWang Z1 aFu X1 aYu G1 aSun L1 aZhang F1 aHong L00aIdentification of ZFP36L1 as an early-onset psoriasis risk gene demonstrates opposite associations with leprosy and psoriasis in the Chinese population.3 a<p>The prevalence of psoriasis in a cohort of leprosy patients is 0.014% (20 cases of concurrent psoriasis in 145,661 leprosy patients), which is much lower than that in the world population. Kumar et al proposed that differences in genetic background are a possible explanation for this. Moreover, in 2012, Bassukas et al first proposed that the expansion of psoriasis-associated genotypes may have resulted from an evolutionary advantage in the form of selection pressure from historical leprosy epidemics in distinct human populations.</p>  a1468-3083