02170nas a2200457   4500000000100000008004100001100001700042700001100059700001100070700001200081700001100093700001000104700001200114700001000126700001100136700000900147700000900156700001100165700000900176700001100185700001000196700001100206700001100217700001100228700001200239700000900251700001100260700000900271700000900280700001000289700001900299700001200318700001000330700001100340245011300351856007100464300001400535490000600549520114300555022001401698       2019                            d1 aChokkakula S1 aChen Z1 aWang L1 aJiang H1 aChen Y1 aShi Y1 aZhang W1 aGao W1 aYang J1 aLi J1 aLi X1 aShui T1 aHe J1 aShen L1 aLiu J1 aWang D1 aWang H1 aChen H1 aKuang Y1 aLi B1 aChen Z1 aWu A1 aYu M1 aYan L1 aSuryadevara NC1 aVissa V1 aLiu W1 aWang H00aMolecular surveillance of antimicrobial resistance and transmission pattern of  in Chinese leprosy patients.  uhttps://www.tandfonline.com/doi/full/10.1080/22221751.2019.1677177  a1479-14890 v83 a<p>Reports on antimicrobial resistance (AMR) of relationship with bacteriological index (BI), and transmission in China are limited. We investigated the emergence of AMR mutations, the relationship between BI and AMR in complete, moderate and lack of BI decline cases, and molecular epidemiological features of AMR cases by enrolling 290 leprosy cases from four endemic provinces. Seven (2.41%), one (0.34%), five (1.72%), one (0.34%), and one (0.34%) strains had single mutations in , , , , and respectively. Double mutations in and , and , and and were observed in one (0.34%) strain each. Mutated strains occurred in three out of 81 (95% CI-0.005-0.079, = 0.083) cases with complete BI decline, in seven out of 103 (95% CI 0.018-0.117, = 0.008) cases with moderate BI decline, and in four out of 34 (95% CI 0.003-0.231, = 0.044) cases with lack of BI decline. Most of these mutated strains were geographically separated and diverged genotypically. AMR mutations may not be the main cause of the lack of BI decline. The low transmission of AMR strains at the county level indicates an ongoing transmission at close contact levels.</p>
  a2222-1751