@article{93847, author = {Wang H and Wang C and Wang Z and Fu X and Yu G and Sun L and Zhang F and Hong L}, title = {Identification of ZFP36L1 as an early-onset psoriasis risk gene demonstrates opposite associations with leprosy and psoriasis in the Chinese population.}, abstract = {

The prevalence of psoriasis in a cohort of leprosy patients is 0.014% (20 cases of concurrent psoriasis in 145,661 leprosy patients), which is much lower than that in the world population. Kumar et al proposed that differences in genetic background are a possible explanation for this. Moreover, in 2012, Bassukas et al first proposed that the expansion of psoriasis-associated genotypes may have resulted from an evolutionary advantage in the form of selection pressure from historical leprosy epidemics in distinct human populations.

}, year = {2020}, journal = {Journal of the European Academy of Dermatology and Venereology : JEADV}, month = {04/2020}, issn = {1468-3083}, doi = {10.1111/jdv.16437}, language = {eng}, }